Figure 4.

PheWAS for polygenic predictors of C3 and C4 levels in 102,138 eMERGE participants. (A and B) Phenome-wide associations of polygenic predictor of C3 levels (A) with HLA region included and (B) without HLA. (C and D) Polygenic predictor of C4 levels (C) with HLA included and (D) without HLA. Selected significant associations are labeled across various organ systems. The red horizontal lines indicate phenome-wide significance level (P=2.8x10^-5) after accounting for the number of phecodes tested.