Table 2.

Top genome-wide significant SNPs in GWAS for C3 and C4 levels, their allelic frequencies, effect estimates (expressed in standard normal units), and P values by ancestry

Locus	Test Allele	European Ancestry			African Ancestry			East Asian Ancestry			Combined Meta-Analysis
		Frequency	β (95% CI)	P Value	Frequency	β (95% CI)	P Value	Frequency	β (95% CI)	P Value	Frequency	β (95% CI)	P Value	I2, %
C3 levels
CFH	rs3753396-A	0.17	0.19 (0.13 to 0.25)	1.52E-09	0.06	0.22 (−0.01 to 0.42)	0.06	0.06	0.45 (0.15 to 0.74)	0.004	0.16	0.20 (0.14 to 0.25)	1.52E-11	26
C3	rs11569470-G	0.14	0.18 (0.12 to 0.23)	1.41E-07	0.05	0.26 (0.01 to 0.51)	0.04	0.05	0.39 (−0.25 to 1.03)	0.23	0.12	0.19 (0.13 to 0.24)	1.29E-08	0
C4 levels
C4	rs3135353-C	0.15	0.40 (0.34 to 0.45)	2.00E-33	0.02	0.28 (−0.07 to 0.63)	0.12	0.05	0.45 (−0.17 to 1.07)	0.16	0.12	0.40 (0.34 to 0.45)	4.58E-35	0
C4	rs6459-T	0.10	0.45 (0.39 to 0.50)	8.04E-30	0.19	0.13 (−0.01 to 0.26)	0.06	0.14	0.48 (0.06 to 0.89)	0.04	0.12	0.38 (0.32 to 0.43)	7.87E-29	87
C4	rs16869834-A	0.05	0.47 (0.37 to 0.56)	2.29E-18	0.06	0.30 (0.01 to 0.50)	0.009	0.04	0.46 (−0.20 to 1.12)	0.17	0.05	0.44 (0.36 to 0.51)	8.28E-20	2
C4	rs9267822-C	0.01	0.61 (0.41 to 0.80)	7.15E-09	0.05	0.64 (0.40 to 0.87)	6.11E-07	0.05	1.08 (0.49 to 1.67)	0.0005	0.02	0.65 (0.51 to 0.78)	6.31E-17	6
C4	rs805285-C	0.25	0.18 (0.14 to 0.22)	1.69E-10	0.36	0.25 (0.13 to 0.36)	1.69E-05	0.48	0.17 (−0.10 to 0.44)	0.23	0.32	0.19 (0.15 to 0.22)	1.44E-14	0
C4	rs17208153-C	0.08	0.28 (0.20 to 0.35)	7.15E-11	0.24	0.16 (0.04 to 0.28)	0.01	0.16	0.01 (−0.36 to 0.38)	0.93	0.11	0.24 (0.18 to 0.30)	2.01E-11	44

I², heterogeneity index for the combined meta-analysis.