Figure 3.

Short-term TWEAK administration before Pkd1 deletion increases the severity of cystic disease in the cystic window. Two TWEAK doses were administered before Pkd1 inactivation at p10–11. (A) Representative images of kidney histology at p30 of control (n=6) and TWEAK-exposed (n=6) mice, additional information in Supplemental Figure 1B. Scale bars, 2 mm (upper panel) and 100 µm (lower panel). (B) BUN and (C) kidney/body weight ratios of control and TWEAK-exposed mice did not change. TWEAK resulted in a significant increase in (D) the cystic index, but did not change (E) the number of cysts. Bars represent means±SEM. *P<0.05.