. 2021 Aug;32(8):1913–1932. doi: 10.1681/ASN.2020071094

Table 1.

Differentially expressed TNFSF and TNFRSF genes with increased expression in PKD

Species	Model	Gene	FC	P Value	Reference (PMID)
Mouse	PKD1−/− embryonic kidneys at days 14.5 versus days 17.5 (GSE24352)	Fn14	2.85	P<0.001	21518438¹¹
	L3-/L3- (PKD mice) versus WT littermates; 3 weeks old	Fn14	3.08	P<0.01	19099603¹²
		Tnfrsf11B	2.29	0.04
		Tnfrsf19	1.95	0.04
	L3−/L3− (PKD mice) versus WT littermates; 3.5 week old	Fn14	1.95	0.01	19099603¹²
		Tnfrsf11B	1.77	0.09
		Tnfrsf19	1.56	0.03
		Tnfr1	1.55	0.02
Rat	Homozygous unaffected (+/+) and heterozygous affected (cy/+) Han:SPRD rats; 36 days old	Fn14	2.32	P<0.001	23326503¹³
		Tnfr1	1.59	P<0.01
		Tnfrsf9	1.40	P<0.001
		Tweak	1.22	P<0.001
		Tnfr2	1.11	P<0.01
	Homozygous unaffected (+/+) and heterozygous affected (cy/+) Han:SPRD rats; 36 days old	Fn14	3.07	P<0.01	19102782¹⁴
		Tnfr1	1.99	P<0.01
		Tweak	1.32	P<0.001
Human	Healthy tissue from patients with PKD versus samples with small cysts (GSE7869)	TNFR2	2.28	P<0.01	31907669¹⁵
		TNFSF13B	2.22	P<0.01
		TNFR1	2.07	P<0.01
		TNFRSF10B	1.99	P<0.01
		TWEAK	1.79	P<0.01
		TNFSF14	1.40	0.0481
		TNFSF9	1.36	0.0243

Transcriptomics databases were searched in PubMed. FC, fold change; PMID, PubMed identifier.