Missing self types cumulatively associate with risk of MVI. (A) Definition of missing self types. (B) Histogram of the possible combinations of missing self types within the study population (n=924). C1 and C2 missing self are mutually exclusive by definition. C1/2DL3 and C1/2DL2 indicate C1 missing self in presence of the KIR2DL2 and KIR2DL3 gene, respectively. (C) Prevalence of specific missing self types in transplantations with and without MVI during histologic follow-up after the baseline biopsy (n=890 transplantations, with 3476 posttransplant biopsies). (D) Number of missing self types in transplantations with and without MVI, chi-squared test for comparison. (E) Kaplan–Meier survival curves for incidence of MVI, censored for recipient death and allograft failure, with groups stratified according to the number of missing self types present within a donor-recipient pair. MS, missing self type. *P<0.05; **P<0.01.