Table 4.
Performance of ROC-derived cut-off values for FIB-4, APRI, and NAFLD Fibrosis score in identification of advanced fibrosis in NAFLD.
| Parameter | Number of patients (%) | Sensitivity (%) | Specificity (%) | Accuracy (%) | PPV (%) | NPV (%) | LRP | LRN | DOR | Youden’s J | p value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall (n = 368) | |||||||||||
| FIB-4 Score | |||||||||||
| FIB-4 > 0.5 | 262 (71) | 97 | 34 | 44 | 21 | 98 | 1.5 | 0.10 | 13.8 | 0.31 | <0.001 |
| FIB-4 > 1.0a | 113 (31) | 88 | 80 | 81 | 45 | 97 | 4.4 | 0.15 | 29.3 | 0.68 | <0.001 |
| FIB-4 > 2.0 | 47 (13) | 57 | 95 | 89 | 70 | 92 | 12.6 | 0.45 | 27.9 | 0.52 | <0.001 |
| APRI Score | |||||||||||
| APRI > 0.15 | 246 (67) | 98 | 39 | 48 | 23 | 99 | 1.61 | 0.04 | 36.5 | 0.37 | <0.001 |
| APRI > 0.29a | 128 (35) | 81 | 72 | 73 | 35 | 95 | 2.9 | 0.26 | 11.1 | 0.53 | <0.001 |
| APRI > 0.9 | 31 (8) | 32 | 96 | 86 | 61 | 88 | 8.46 | 0.70 | 12.1 | 0.28 | <0.001 |
| NAFLD Fibrosis Score (NFS) | |||||||||||
| NFS > -3.5 | 337 (92) | 96 | 9 | 23 | 17 | 94 | 1.07 | 0.37 | 2.9 | 0.05 | 0.137 |
| NFS > –0.4a | 159 (43) | 79 | 64 | 66 | 29 | 94 | 2.18 | 0.33 | 6.6 | 0.43 | <0.001 |
| NFS > 1.8 | 34 (9) | 24 | 94 | 83 | 41 | 87 | 3.74 | 0.81 | 4.6 | 0.18 | <0.001 |
FIB-4 fibrosis 4 score, APRI aspartate aminotransferase to platelet ratio index, NAFLD non-alcoholic fatty liver disease, PPV positive predictive value, NPV negative predictive value, LRP likelihood ratio positive, LRN likelihood ratio negative, DOR diagnostic odds ratio.
aMost suitable threshold according to ROC analysis and Youden’s J statistic.