Table 3.
Cluster 2 vs full SomaLogic protein enrichment results for disease class using DAVID bioinformatics 6.8 [31].
| Term (Genetic Association Database disease class) | Count | % | List total | Population hits | Population total | Fold enrichment | P value | Bonferroni-adjusted P value |
|---|---|---|---|---|---|---|---|---|
| Cardiovascular | 439 | 34.1 | 1024 | 1023 | 2723 | 1.14 | 7.3E−06 | 1.3E−04 |
| Renal | 216 | 16.8 | 1024 | 472 | 2723 | 1.22 | 5.8E−05 | 1.0E−03 |
| Cancer | 401 | 31.2 | 1024 | 958 | 2723 | 1.11 | 5.3E−04 | 9.5E−03 |
| Pharmacogenomic | 357 | 27.8 | 1024 | 856 | 2723 | 1.11 | 1.9E−03 | 3.4E−02 |
| Metabolic | 504 | 39.2 | 1024 | 1243 | 2723 | 1.08 | 2.4E−03 | 4.2E−02 |
| Vision | 100 | 7.8 | 1024 | 216 | 2723 | 1.23 | 5.9E−03 | 1.0E−01 |
| Haematological | 168 | 13.1 | 1024 | 388 | 2723 | 1.15 | 9.8E−03 | 1.6E−01 |
| Reproduction | 152 | 11.8 | 1024 | 351 | 2723 | 1.15 | 1.4E−02 | 2.3E−01 |
| Immune | 360 | 28.0 | 1024 | 886 | 2723 | 1.08 | 1.5E−02 | 2.4E−01 |
| Neurological | 311 | 24.2 | 1024 | 759 | 2723 | 1.09 | 1.6E−02 | 2.5E−01 |
| Aging | 117 | 9.1 | 1024 | 278 | 2723 | 1.12 | 7.5E−02 | 7.5E−01 |