Table 5.
Distribution of genotypes and allele frequencies of AHRR among patients with rheumatoid arthritis RA with good and poor response to MTX treatment adjusted by age.
| SNP/genetic model | Genotype | Good responders n (%) | Poor responders n (%) | OR (95% CI) | p value |
|---|---|---|---|---|---|
| AHRR rs34453673 (G/C) | |||||
| Codominant | G/G | 15 (32.6) | 33 (35.5) | 1 | 0.36 |
| G/C | 20 (43.5) | 45 (48.4) | 1.0 (0.44–2.32)1 | ||
| C/C | 11 (23.9) | 15 (16.1) | 0.52 (0.18–1.45) | ||
| Dominant | G/G | 15 (32.6) | 33 (35.5) | 1 | 0.65 |
| G/CC/C | 31 (67.4) | 60 (64.5) | 0.84 (0.39–1.8) | ||
| Recessive | G/GG/C | 35 (76.1) | 78 (83.9) | 1 | 0.15 |
| C/C | 11 (23.9) | 15 (16.1) | 0.51 (0.21–1.27) | ||
| Overdominant | G/GC/C | 26 (56.5) | 48 (51.6) | 1 | 0.5 |
| G/C | 20 (43.5) | 45 (48.4) | 1.29 (0.62–2.66) | ||
| log-Additive | 46 (33.1) | 93 (66.9) | 0.75 (0.45–1.26) | 0.27 | |
| AHRR rs2292596 (C/G) | |||||
| Codominant | C/C | 17 (37.8) | 28 (31.5) | Reference | 0.33 |
| C/G | 17 (37.8) | 43 (43.8) | 1.87 (0.79–4.45) | ||
| G/G | 11 (24.4) | 18 (20.2) | 1.19 (0.43–3.25) | ||
| Dominant | C/C | 17 (37.8) | 28 (31.5) | Reference | 0.24 |
| C/GG/G | 28 (62.2) | 61 (68.5) | 1.6 (0.73–3.53) | ||
| Recessive | C/CC/G | 34 (75.6) | 71 (79.8) | Reference | 0.69 |
| G/G | 11 (24.4) | 18 (20.2) | 0.83 (0.34–2.02) | ||
| Overdominant | C/CG/G | 28 (62.2) | 46 (51.7) | 1 | 0.15 |
| C/G | 17 (37.8) | 43 (48.3) | 1.75 (0.81–3.76) | ||
| log-Additive | 45 (33.6) | 89 (66.4) | 1.15 (0.69–1.92) | 0.6 |