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. 2021 Jul 12;45(10):2252–2260. doi: 10.1038/s41366-021-00888-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Signed Manhattan-type plot presenting the analysis of the 4714 UPLC-MS metabolic features for Model 1 for A rapid growth at twelve months of age and for B overweight in early childhood. The red dots represent the features that remain significant after applying the FDR threshold of 5%, whereas blue dots do not. The vertical axis shows the signed −log10 P value. The horizontal axis represents the monoisotopic mass (in Da). UPLC-MS-associated metabolic features are available in Table S3 and Table S6. The dotted green line represents the mass density.