Table 3.
Top canonical pathways potentially regulated by H3K4me3 histone modification
| Ingenuity canonical pathways | P value | Activation z-score |
|---|---|---|
| Crosstalk between Dendritic Cells and Natural Killer Cells | 4.90E-02 | 2.24 |
| Glycolysis I | 1.12E-02 | 2.24 |
| Interferon Signaling | 4.17E-02 | 2.24 |
| Insulin Secretion Signaling Pathway | 6.03E-03 | 2.13 |
| PKCθ Signaling in T Lymphocytes | 3.98E-02 | 2.11 |
| Gluconeogenesis I | 4.79E-02 | 2.00 |
| iCOS-iCOSL Signaling in T Helper Cells | 1.58E-02 | 1.90 |
| Neuroinflammation Signaling Pathway | 3.24E-02 | 1.70 |
| Inhibition of Matrix Metalloproteases | 1.70E-02 | 1.63 |
| IL-15 Production | 7.59E-04 | -2.00 |
| HOTAIR Regulatory Pathway | 4.79E-06 | -2.04 |
| Cyclins and Cell Cycle Regulation | 3.89E-03 | -2.11 |
| PEDF Signaling | 3.16E-02 | -2.12 |
| Sonic Hedgehog Signaling | 3.89E-03 | -2.24 |
| Regulation Of The Epithelial Mesenchymal Transition | 4.68E-02 | -2.31 |
| Fibrosis Signaling Pathway | 8.91E-03 | -2.41 |
| Semaphorin Neuronal Repulsive Signaling Pathway | 2.24E-02 | -2.50 |
| Kinetochore Metaphase Signaling Pathway | 1.55E-06 | -2.67 |
| GP6 Signaling Pathway | 6.31E-04 | -3.00 |
| Cell Cycle Control of Chromosomal Replication | 3.39E-05 | -3.46 |