Table 5.
Top canonical pathways potentially regulated by H3K27Ac histone modification
| Ingenuity canonical pathways | P value | Activation z-score |
|---|---|---|
| Insulin Secretion Signaling Pathway | 8.13E-05 | 2.60 |
| Leptin Signaling | 7.59E-03 | 2.00 |
| Gluconeogenesis I | 3.16E-02 | 2.00 |
| 3-phosphoinositide Biosynthesis | 2.45E-02 | 1.39 |
| AMPK Signaling | 1.23E-02 | 1.29 |
| Wnt/PCP Pathway | 6.76E-03 | -2.12 |
| Wnt/Ca + Pathway | 8.13E-03 | -2.12 |
| GP6 Signaling Pathway | 1.00E-02 | -2.31 |
| Semaphorin Neuronal Repulsive Signaling Pathway | 1.91E-02 | -2.31 |
| Cyclins and Cell Cycle Regulation | 1.35E-02 | -2.33 |
| Mitotic Roles of Polo-Like Kinase | 1.78E-06 | -2.45 |
| Estrogen-mediated S-phase Entry | 1.07E-03 | -2.45 |
| HOTAIR Regulatory Pathway | 1.41E-03 | -2.67 |
| Regulation Of The Epithelial Mesenchymal Transition In Development Pathway | 1.86E-03 | -2.71 |
| IL-15 Production | 1.15E-02 | -2.89 |
| Cell Cycle Control of Chromosomal Replication | 3.16E-13 | -4.02 |