Table 1.

Relative proportion of non-REM and REM sleep over total sleep time during the first 6 h of the night period following oral administration of daridorexant or zolpidem to rats

Daridorexant			Zolpidem
	% over total sleep time			% over total sleep time
	Non-REM sleep	REM sleep		Non-REM sleep	REM sleep
Vehicle	71.4 ± 5.6	28.6 ± 5.6	Vehicle	85.5 ± 1.6	14.5 ± 1.6
10 mg/kg	73.6 ± 3.8	26.4 ± 3.8	3 mg/kg	87.2 ± 1.0	12.8 ± 1.0
30 mg/kg	70.8 ± 4.1	29.2 ± 4.1	10 mg/kg	89.5 ± 1.2	10.5 ± 1.2*
100 mg/kg	71.7 ± 2.3	28.3 ± 2.3	30 mg/kg	94.0 ± 0.9	6.0 ± 0.9**
300 mg/kg	78.6 ± 2.1	21.4 ± 2.1

Data are expressed as mean ± standard error of the mean. One-way ANOVA followed by the post-hoc Dunnett’s multiple comparisons test: *p < 0.05; **p < 0.001 vs. vehicle-treated rats. N = 8 male Wistar rats per dose group. REM rapid eye movement. Data-on-file. Full experimental details provided by Boss et al. 2020