Figure 2.

RGS14 KO mice exhibit attenuated novelty-induced locomotion (NIL) and increased thigmotaxis but show no deficits in novelty detection or within-trial habituation. a Experimental timeline for NIL experiment and schematic of locomotor testing chamber. b Locomotor activity measured in 5-min bins over 1 h in a novel environment for WT (blue) and KO (red) mice. Ambulations decreased over time for both genotypes as mice habituated to the novel environment, but the reduction in activity was greater in KO compared to WT. c KO mice exhibited fewer total ambulations than WT during the NIL test. d While peripheral ambulations were similar between WT (blue, solid bar) and RGS14 KO mice (red, solid bar), KO mice made fewer center ambulations (red, striped bar) than WT (blue, striped bar), indicative of increased thigmotaxis. n = 19 – 20 per genotype. n.s. = not significant, *p < 0.05, **p < 0.01. Created with BioRender.com.