. 2021 Sep 17;16:6413–6426. doi: 10.2147/IJN.S319255

Table 3.

Pharmacokinetic Parameters of DAC Suspension, DAC-unPEG-BILS, and DAC-PEG-BILS in Rat Liver Following Oral Administration (n=6)

Parameters	DAC Suspension	DAC-UnPEG-BILS	DAC-PEG-BILS
C_max (ng.mL⁻¹)	1205±13.32	1596±20.39^a	1938±14.41^{a, b}
T_max (h)	2±0.09	2.7±0.21^a	3±0.17^{a, b}
AUC_0–24(h.ng.mL⁻¹)	9673±13.69	20,698±16.32^a	29,895±19.39^{a, b}
t_½ (h)	11±0.14	13.46±0.14^a	15.66±0.14^{a, b}
CL (L.h⁻¹)	1.20±0.11	0.57±0.03^a	0.4±0.04^{a, b}

Notes: Values are means ± SD. Using one-way ANOVA followed by Tukey’s post-hoc test: ^ap<0.05 vs DAC suspension; ^bp<0.05 vs DAC-unPEG-BILS.