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. 2021 Sep 21;11:18765. doi: 10.1038/s41598-021-97710-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The Cytoscape visualization of STRING-generated network composed of experimentally verified protein–protein interactions among the quantified proteins (a) for serum and (b) for plasma. Nodes with a bold edge correspond to proteins with statistically significant change between the groups (p value < 0.05), whereas nodes with grey edges correspond to proteins with a verified interaction with those proteins and at least twofold concentration change between the groups, which was however insignificant (p value > 0.05). The gradation of the fill corresponds to the value of the concentration fold changes, the darker the greater the change, shades of red and blue correspond to increased and decreased concentration in the test group, respectively.