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. 2021 Sep 21;4:1107. doi: 10.1038/s42003-021-02621-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a, b Scatter plot showing the percentage of DNA methylation at each CpG site among TARDBP 3′UTR CpGs 10–15 according to age at autopsy (Pearson’s correlation test) in the control (a) and ALS (b) groups. c Scatterplot showing the average DNA methylation of 3′UTR CpGs 10–15 according to age at autopsy in the controls (Pearson’s correlation test). d Proportions of the number of sequence reads classified by the number of methylated CpGs among the six CpG sites (3′UTR CpGs 10–15) in the controls and ALS patients. e Correlation between age at autopsy and the epipolymorphism scores of 3′UTR CpGs 10–15 (Pearson’s correlation test). f, g Methylation-linkage diagram of 3′UTR CpGs 10–15 in two of the youngest and two of the oldest individuals analyzed (f) and heat map (g) showing the extent of the pairwise correlation of each CpG pair. h For each DNA methylation profile, the effects of the targeted manipulation of DNA methylation, differences according to brain region, and the effect of aging are shown as fold changes (log2) relative to the experimental control, liver, and middle-aged group results, respectively.