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. 2021 Sep 21;4:1107. doi: 10.1038/s42003-021-02621-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — a “Epigenetic age” is estimated based on the regression coefficient calculated from the chronological age and the DNA methylation percentages at TARDBP 3′UTR CpG 10 in the control motor cortex (11 controls). The difference between the epigenetic age and the linear-regression model is defined as “DNA methylation age acceleration” in the ALS cases. Ten ALS patients were included in the analysis in relation to the clinical features. b Scatterplot showing the age at disease onset according to DNA methylation age acceleration at 3′UTR CpG 10. c Scatterplot showing the acceleration of the DNA methylation age at 3′UTR CpG 10 according to the disease duration. Pearson’s correlation test.