Skip to main content
. 2021 Sep 21;7:256. doi: 10.1038/s41420-021-00639-1

Fig. 5. Tf-Pep63-Lip and Tf-Lip rescue the surface expression of EphB2 and GluN2B-containing NMDA receptors in the hippocampus of APP/PS1 transgenic mice.

Fig. 5

a Intravenous administration of Tf-Pep63-Lip and Tf-Lip at a lipid dose of 5 mg/kg for 30 days significantly rescued the reduced surface expression of EphB2 in APP/PS1 transgenic mice (APP) (n = 5). b Tf-Pep63-Lip and Tf-Lip significantly increased the reduced surface expression of GluN2B subunits in APP/PS1 transgenic mice (n = 5). c Tf-Pep63-Lip and Tf-Lip remarkably enhanced the phosphorylation levels of GluN2B at pY1472 (p-GluN2B) in APP/PS1 transgenic (n = 5). d Tf-Pep63-Lip and Tf-Lip did not affect the total expression of GluN2B subunits in APP/PS1 transgenic mice (n = 5). *P < 0.05, **P < 0.01, ****P < 0.0001, significantly different. Data are presented as means ± SEM.

HHS Vulnerability Disclosure