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. 2021 Sep 21;7:256. doi: 10.1038/s41420-021-00639-1

Fig. 6. Tf-Pep63-Lip and Tf-Lip do not induce adverse effects in vivo and in vitro.

Fig. 6

a No pathological changes were found in the main organs after 30 days of treatment with Tf-Pep63-Lip, Tf-Lip, or NS in 6-month-old APP/PS1 and WT mice (n = 3). b Administration of Tf-Pep63-Lip, Tf-Lip, or NS did not affect the motor function of APP/PS1 and WT mice (n = 5). c The weight of APP/PS1 and WT mice did not change after 30 days of treatment with Tf-Pep63-Lip, Tf-Lip, or NS (n = 8). d–f The viability of hippocampal primary neurons (d), astrocytes (e), and microglia (f) showed no significant change after incubation with 2.5 µg/ml Pep63, lipid doses of 72.5 µg/ml Tf-Lip and Tf-Pep63-Lip for 4 h (n = 5). Data are presented as means ± SEM.