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. 2021 Sep 21;11:18750. doi: 10.1038/s41598-021-98407-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The presence of collagen-derived peptides in the blood after consuming the different peptides. Mice with the abdominal surgery were fed a normal diet and consumed just water (HO) or water that contained milk-derived casein (CS), high molecular weight collagen peptides (HP), and low molecular weight collagen peptides (LP) for 21 days. After the study was completed, collagen peptides in the plasma were measured using a LC–MS/MS technique. Higher contents of peptides were detected in the following groups Hyp-Gly, Pro-Hyp, Gly-Pro-Hyp, and Pro-Hyp-Gly. The comparison was done between the levels on day 0 and day 21 in the same group and between the groups on day 21. N = 5 or 6/group, Mean ± SE, ^#p > 0.1, *p < 0.05.