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. 2021 Sep 21;4:1109. doi: 10.1038/s42003-021-02630-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — MDA in plasma (a) and in the aortic root lesions (b, c) from Pcyox1^+/+/Apoe^−/− (n = 8) and Pcyox1^−/−/Apoe^−/− (n = 11) mice fed a HFD for 8 weeks. b Representative images of MDA immunostaining (upper panels) and negative control sections incubated with no primary antibody (lower panels); c results of the morphometric analysis of MDA-stained sections, expressed either as absolute positive areas within the intima or as the percentage of total lesion area. Data are presented as circle plot, with each circle representing an individual mouse and bars showing the mean value ± SEM. p < 0.05 or p < 0.01 by Student’s t test. d–g mRNA levels normalized to the housekeeping gene 18S rRNA of Il6 (d), Tnf (e), Icam1 (f), and Serpine1 (g) in macrophages isolated from Pcyox1^+/+/Apoe^−/− and Pcyox1^−/⁻/Apoe^−/− mice and treated with LPS 5 ng/mL for 2 h. Data are expressed as fold increase induced by LPS with respect to unstimulated cells and presented as circle plot, with each circle representing an individual mouse and bars showing the mean value ± SEM (n = 5). p < 0.05 by Student’s t test.