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. 2021 Sep 21;6:76. doi: 10.1038/s41525-021-00239-z

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© This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2021

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Fig. 1 — Flowchart depicting TARGETS model training on DNA and RNA sequencing data from the Genomics of Drug Sensitivity in Cancer (GDSC) database to predict drug response. Model training was performed utilizing Elastic Net regression. The drug models were locked and subsequently validated on three independent cohorts: the Cancer Cell Line Encyclopedia (CCLE), The Cancer Genome Atlas (TCGA) pan-cancer database, and the West Coast Dream Team (WCDT) metastatic prostate cancer database.