Table 1.
Meta-analyses of HLA alleles association.
| Allele | Freq cases | Freq controls | OR (95% CI) | P value1 | Direction | HetPVal |
|---|---|---|---|---|---|---|
| DQA1*03:01 | 0.168 | 0.185 | 0.86 (0.81-0.90) | 3.54e−08 | – | 0.85 |
| DQB1*03:02 | 0.182 | 0.199 | 0.87 (0.83-0.92) | 7.62e−07 | – | 0.58 |
| DRB1*04:01 | 0.187 | 0.221 | 0.89 (0.84-0.94) | 2.82e−05 | – | 0.87 |
| DRB1*04:04 | 0.068 | 0.082 | 0.84 (0.77-0.91) | 8.21e−05 | – | 0.85 |
Freq cases carrier frequency of allele in patients, Freq controls carrier frequency of an allele in controls, OR (95% CI) odds ratio and 95% confidence interval, Direction direction of beta for each cohort, HetPVal P value of heterogeneity.
1Bonferroni correction for multiple comparisons sets the threshold for statistical significance to α = 3.55 × 10−4.