Fig. 9.

Application of PRS to scan for residues associated with the conformational shift from a closed to an opened flap conformation in HIV protease. The front (A) and (B) top views of the protease are shown, with an arrow depicting the protease flaps. The correlation mappings default to the range [0, 1], with a color gradient ranging from yellow to dark red, but can also be scaled to the range of the observed correlations by clicking on the “Min-max scaling” option when signals have a narrower range.