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. 2021 Sep 21;12(10):857. doi: 10.1038/s41419-021-04162-0

Fig. 1. Nobiletin more dramatically suppressed the proliferation of AR/AR-V7-positive prostate cancer cells.

Fig. 1

A Left: CCK8 assays of WPMY-1, PC3, DU145, 22Rv1, and C4-2 cells exposed to nobiletin for 48 h. Mean ± SD (n = 3), Nob nobiletin. Right: the IC50 values of nobiletin on different cells. B EdU staining assays of 22Rv1 and PC3 cells exposed to nobiletin for 24 h. Quantitative data are shown. Mean ± SD (n = 3). C Colony formation assays of 22Rv1, and PC3 cells exposed to nobiletin for 2 weeks. D Quantification of C are shown. Mean ± SD (n = 3). E Apoptosis analysis of 22Rv1 and PC3 cells treated with nobiletin for 24 h. F Quantification of E are shown. Mean ± SD (n = 3).