Table 4.

IL-6 level in DFU swab base on intervention.

Intervention	A-PRF + HA (n = 10)	A-PRF (n = 10)	Control (n = 10)	p-value
Before∗	106.4 (83.1–407.6)	91.9 (38.6–151.6)	125.3 (20.3–287.0)	0.337
After day-3∗	99.5 (76.3–302.2)	72.8 (27.1–148.9)	131.1(5.3–337.5)	0.119
After day-7∗	88.7 (44.3–217.9)	48.8 (27.7–156.2)	167.9 (27.7–156.2)	0.041

IL-6 in A-PRF + AH compare with A-PRF decrease not significant on day-3 (p = 0.226), but significant decrease on day-7 (Mann Whitney test, p = 0,023).

IL-6 in A-PRF + AH decrease significantly compare with control on day-3 (Mann Whitney test, p = 0,049) and day -7 (Mann Whitney test, p = 0,041).

IL-6 in A-PRF decrease not significant compare with control on day-3 (Mann Whitney test, p = 0,326) and day -7 (Mann Whitney test, p = 0,545).

^∗Data median (min-max), Kruskal Wallis test.