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Serotonin levels (nM ± SEM) in the IPN of female (control n = 6; nicotine-treated n = 6) and male (control n = 6; nicotine-treated n = 6) rats. The top panels reflect raw dialysate levels and the bottom panel reflects percentchange in nicotine-treated female and male rats relative to their respective controls. Each point reflects a 20-min sampling period during baseline and then following mecamylamine administration to precipitate withdrawal (shaded area)
