Table 2.

Personal and familial autoimmune disease.

	DS/MMS (n = 52) % (95% CI)	MMD (n = 77) % (95% CI)	DS (n = 1217) % (95% CI)	p-value
AUTOIMMUNE DISEASE
Any Thyroid Disorders TPO Ab positive (n, % of tested) Anti-Tg Ab positive (n, % of tested) Type I DBM GAD65 Ab positive (n, % of tested) Celiac Vitiligo JIA SLE Other	54 (39, 68) 27 (16, 41) 12, 92 11, 85 12 (4, 23) 6, 100 8 (2, 19) 0 (–, –) 6 (1, 16) 0 (–, –) 2 (0, 10)	17 (9, 27) 8 (3, 16) 1, 20 1, 20 4 (1, 11) 1, 100 3 (0, 9) 1 (0, 7) 0 (–, –) 0 (–, –) 1 (0, 7)	35 (33, 38) 16 (14, 18) 75, 39 75, 39 3 (2, 4) 17, 81 5 (4, 6) 1 (1, 2) 2 (1, 3) 0 (0, 1) 8 (7, 10)	<0.001 0.014 0.012 0.426 0.732 0.084 1.000 0.018
>1 Autoimmune disorder	15 (7, 28)	0 (–, –)	5 (4, 6)	<0.001
1 st DEGREE RELATIVE WITH AUTOIMMUNE DISEASE
Any Thyroid Disorder Type I DBM Celiac RA Vitiligo Alopecia Ulcerative Colitis Other	46 (32, 61) 6 (1, 16) 0 (–, –) 4 (0, 13) 8 (2, 19) 0 (–, –) 0 (–, –) 4 (0, 13) 25 (14, 39)	25 (16, 36) 12 (5, 21) 3 (0, 9) 3 (0, 9) 3 (0, 9) 1 (0, 7) 1 (0, 7) 0 (–, –) 3 (0, 9)	7 (5, 8) 5 (3, 6) 0 (0, 1) 0 (0, 1) 0 (0, 2) 1 (0, 1) 0 (0, 0) 0 (–, –) 0 (0, 1)	<0.001 0.027 0.106 0.004 0.001 0.261 0.183 0.001 <0.001
TPO Antibodies
Positive Negative Not Testeda	52 (38, 66) 31 (19, 45) 17 (8, 30)	12 (5, 21) 32 (22, 44) 56 (44, 67)	9 (7, 11) 30 (27, 33) 61 (58, 64)	<0.001a
Anti-Tg Antibodies
Positive Negative Not Testeda	46 (32, 61) 36 (24, 51) 17 (8, 30)	10 (5, 19) 34 (23, 45) 56 (44, 67)	9 (7, 11) 30 (27, 33) 61 (58, 64)	<0.001a
GAD65 Antibodies
Positive Negative Not Testeda	25 (14, 39) 31 (19, 45) 44 (30, 59)	5 (1, 13) 26 (17, 37) 69 (57, 79)	2 (1, 3) 17 (15, 19) 81 (79, 83)	<0.001a

DBM, diabetes mellitus; GAD, glutamic acid decarboxylase; JIA, juvenile idiopathic arthritis; SLE, systemic lupus erythematosus; TPO, thyroid peroxidase; Tg, thyroglobulin.

^aIndividuals who were not tested for autoantibodies were excluded from analysis, thus p values are a representation of positive and negative values in a limited cohort.