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. 2021 Sep 8;12:724969. doi: 10.3389/fneur.2021.724969

Table 3.

Clinical data for individuals with co-morbid autoimmune disorders.

DS/MMS AI (n = 28) % (95% CI) DS/MMS Non-AI (n = 24)
% (95% CI)
MMD AI (n = 13) % (95% CI) MMD Non-AI (n = 64)
% (95% CI)
DS AI (n = 428) % (95% CI) DS Non-AI (n = 789)
% (95% CI)
Male sex 50 (30, 69) 38 (19, 59) 31 (9, 61) 44 (31, 57) 47 (43, 52) 48 (44, 54)
Race/Ethnicity
Caucasian
Hispanic
Asian
Black
Other
89 (72, 98)
39 (22, 59)
7 (1, 24)
4 (0, 18)
0 (–, –)
79 (58, 93)
33 (16, 55)
13 (3, 32)
4 (0, 21)
4 (0, 21)
54 (25, 81)
54 (25, 81)
31 (9, 61)
15 (2, 45)
0 (–, –)
77 (64, 86)
38 (26, 50)
19 (10, 30)
3 (0, 11)
2 (0, 1)
88 (84, 91)
36 (31, 40)
9 (7, 13)
3 (2, 5)
0 (–, –)
86 (84, 89)
35 (32, 39)
9 (7, 12)
4 (3. 5)
1 (0, 2)
Age (median, IQR) 14 (7.5–17) 12 (8.25–17) 15 (13–17) 12.5 (6.5–17) 11 (7–15) 11 (7–15)
TPO Antibodies
Positive
Negative
Not Tested
75 (55, 89)
14 (4, 33)
11 (2, 28)
25 (10, 47)
50 (29, 71)
25 (10, 47)
8 (0, 36)
62 (32, 86)
31 (9, 61)
13 (6, 23)
27 (16, 39)
61 (48, 73)
22 (18, 26)
42 (38, 47)
36 (31, 40)
2 (1, 3)
23 (20, 26)
75 (72, 78)
Anti-Tg Antibodies
Positive
Negative
Not Tested
64 (44, 81)
25 (11, 45)
11 (2, 28)
25 (10, 47)
50 (29, 71)
25 (10, 47)
8 (0, 36)
62 (32, 86)
31 (9, 61)
11 (5, 21)
28 (18, 41)
61 (48, 73)
22 (18, 26)
42 (38, 47)
36 (31, 40)
2 (1, 3)
23 (20, 26)
75 (72, 78)
GAD65 Antibodies
Positive
Negative
Not Tested
39 (22, 59)
29 (13, 49)
32 (16, 52)
8 (1, 27)
33 (16, 55)
58 (37, 78)
8 (0, 36)
16 (2, 45)
77 (46, 95)
5 (1, 13)
28 (18, 41)
67 (54, 78)
5 (3, 7)
23 (19, 27)
72 (68, 76)
0 (–, –)
14 (11, 16)
86 (83, 88)
MOYAMOYA CLINICAL DATA
Presenting with CVA 71 (51, 87) 71 (49, 87) 46 (19, 75) 72 (59, 82)
Collaterals Present 71 (51(87) 88 (68, 97) 77 (46, 95) 81 (70, 90)
Laterality
Bilateral
Unilateral
Left
Right
68 (48, 84)
32 (16, 52)
21 (8, 41)
11 (2, 28)
79 (58, 93)
21 (7, 42)
13 (3, 32)
8 (3, 17)
77 (46, 95)
23 (5, 54)
15 (2, 45)
8 (0, 36)
80 (68, 89)
20 (11, 32)
13 (6, 23)
5 (38.5)
Suzuki Grade (median, IQR) 3.0 (2–4) 3 (3–4) 3 (2–4) 3 (2.75–5)
Hemorrhage 0 (–, –) 0 (–, –) 0 (–, –) 5 (1, 13)
Aneurysm 4 (0, 18) 0 (–, –) 0 (–, –) 0 (–, –)
Posterior Circulation Involvement
TPO positive
18 (6, 37)
82 (63, 94)
38 (19, 59)
63 (41, 81)
15 (2, 45)
85 (55, 98)
20 (11, 32)
80 (68, 89)

AI, Autoimmune disease; CVA, cerebrovascular accident; GAD, glutamic acid decarboxylase; IQR, interquartile range; NS, non-significant; TPO, thyroid peroxidase; Tg, thyroglobulin.