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. 2021 Sep 8;12:704639. doi: 10.3389/fneur.2021.704639

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Copyright © 2021 Wang, Wei, Cui, Li, Gu, Gu, Li and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Common affected systems and related phenotypes in neurofibromatosis type 1 (NF1) patients. Diverse clinical features present due to the NF1 gene mutations in different cell types including melanocytes, neurons, neuroglial cells, osteoblasts, etc. (A) Lisch nodules, (B) cafe-au-lait macules, (C) cutaneous neurofibromas, (D) plexiform neurofibromas, (E,F) gliomas, (G) scoliosis, (H) pseudoarthrosis. Images are used with patient permission.