TABLE 1.

Summary of ferroptosis associated oncogenes and tumor suppressors.

Gene	Target	Regulatory direction for target	Effect to ferroptosis (references)
HRASV12	iron metabolism related genes	activation	reduce erastin sensibility (Yagoda et al., 2007; Yang et al., 2014)
HRASV12	iron storage proteins	inhibition	enhance ferroptosis (Yagoda et al., 2007; Yang et al., 2014)
HRASV12	GSH system	activation	reduce erastin sensibility (Schott et al., 2015)
NRASV12	GSH system	activation	reduce erastin sensibility (Schott et al., 2015)
KRASV12	GSH system	activation	reduce erastin sensibility (Schott et al., 2015)
ARF6	ACSL4	inhibition	enhance RSL3 sensibility (Ye et al., 2020)
p53R237H	NRF2/SLC7A11	regulation	suppress cystine/glutamate antiporter (Sasaki et al., 2002; Habib et al., 2015; Liu D.S. et al., 2017)
p53R175H	NRF2/SLC7A11	regulation	suppress cystine/glutamate antiporter (Sasaki et al., 2002; Habib et al., 2015; Liu D.S. et al., 2017)
p533KR	SLC7A11	inhibition	suppress cystine/glutamate antiporter (Jiang et al., 2015)
p53	SLC7A11	inhibition	suppress cystine/glutamate antiporter (Sasaki et al., 2002; Habib et al., 2015; Liu D.S. et al., 2017)
p53	p53-SAT1-ALOX15 axis	activation	enhance ferroptosis (Chu et al., 2019)
p53	GLS2	activation	enhance GSH generation (Hu et al., 2010)
p53	DPP4	regulate the localization and activity	inhibit ferroptosis (Xie et al., 2017)
p53	CDKN1A	activation	delay the onset of ferroptosis (Tarangelo et al., 2018)
MDM2 and MDMX	p53	inhibition	enhance ferroptosis (Venkatesh et al., 2020)
Myc	EGLN1-HIF-1α-LSH-WDR76 axis	activation	inhibit ferroptosis (Jiang et al., 2017)
Myb	CDO1-GPX4 axis	suppress CDO1, and promote GPX4	inhibit ferroptosis (Prouse and Campbell, 2012; Hao et al., 2017)
Src	GPXs	Src acts as the target for GPXs	participate in ferroptosis regulation (Wei J. et al., 2020)
Src	ACSL4	inhibition	inhibit ferroptosis (Brown et al., 2017)