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. 2021 Sep 8;9:714996. doi: 10.3389/fcell.2021.714996

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Copyright © 2021 Liu, Liu, Wang, Wan, Liu and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dexmedetomidine (Dex) mitigated chronic constriction injury (CCI)-induced neuropathic pain. (A) Paw withdrawal threshold (PWT) (g) at 0, 1, 3, 7, and 14 days after operation. (B) Paw withdrawal latency (PWL) (s) at 0, 1, 3, 7, and 14 days after operation. (C) IL-1β, IL-6, and TNF-α expression levels were determined using enzyme-linked immunosorbent assay. (D) mRNA levels of caspase-9, Bax, and Bak in spinal cord tissues were determined using quantitative polymerase chain reaction. (E) Protein levels of caspase-9, Bax, and Bak in spinal cord tissues were determined using western blotting. **P < 0.01, ***P < 0.001 vs. Sham group; ^##P < 0.01 vs. CCI group.