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. 2021 Sep 8;9:714996. doi: 10.3389/fcell.2021.714996

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Copyright © 2021 Liu, Liu, Wang, Wan, Liu and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Role of Dex in Keap1–Nrf2 pathway expression and activation in CCI-induced rats. (A,B) mRNA expression levels of Keap1 and Nrf2 were measured using quantitative polymerase chain reaction (qPCR). (C) mRNA expression levels of HO-1 were measured using qPCR. (D) Isolated microglia were transfected with ARE luciferase vector, followed by determination of luciferase activity in the cells at 36 h after transfection. (E) Protein expression levels of Nrf2, Keap1, and HO-1 were measured using western blotting. (F) Immunohistochemical staining of Keap1 and Nrf2 expression in spinal cord tissues. Scale bar, 50 μm. *P < 0.05, **P < 0.01 vs. Sham group; ^#P < 0.05, ^##P < 0.01 vs. CCI group.