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. 2021 Sep 8;9:714996. doi: 10.3389/fcell.2021.714996

FIGURE 5.

FIGURE 5

Effect of Keap1 overexpression on Dex-alleviated neuropathic pain in CCI-induced rats intrathecally injected with lentiviral-NC/lentiviral-Keap1 for 1 week. Rats were then subjected to Dex treatment and CCI surgery. (A) Paw withdrawal threshold (g) at 0, 1, 3, 7, and 14 days after operation. (B) Paw withdrawal latency (s) at 0, 1, 3, 7, and 14 days after operation. (C) IL-1β, IL-6, and TNF-α expression levels were measured in spinal cord tissues using ELISA. (D) mRNA expression levels of caspase-9, Bax, and Bak were determined in spinal cord tissues using quantitative polymerase chain reaction. (E) Protein expression levels of caspase-9, Bax, and Bak in spinal cord tissues were determined using western blotting. *P < 0.05, **P < 0.01 vs. CCI group; #P < 0.05, ##P < 0.01 vs. CCI+Dex group.