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. 2021 Sep 8;9:714996. doi: 10.3389/fcell.2021.714996

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Copyright © 2021 Liu, Liu, Wang, Wan, Liu and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of Keap1 overexpression on Dex-alleviated antioxidant capacity in spinal cord tissues of rats. Rats were intrathecally injected with lentiviral-NC or lentiviral-Keap1 for 1 week and then subjected to Dex treatment and CCI surgery. (A) Levels of antioxidant genes in the spinal cord were determined using quantitative polymerase chain reaction. (B) Analysis of glutathione levels in spinal cord tissue. (C) Superoxide dismutase activity in spinal cord tissues was examined using a SOD assay kit. (D) Analysis of catalase activity. *P < 0.05, **P < 0.01 vs. CCI group; ^#P < 0.05, ^##P < 0.01 vs. CCI+Dex group.