TABLE 4.

NDD-causing genes encoding proteasome subunits and associated syndromes.

Gene	OMIM	Syndrome	References	Described regulator of	References
PSMD12	617516	STANKIEWICZ-ISIDOR SYNDROME	Kury et al. (2017)	Inflammation	Ebstein et al. (2019); Cetin et al. (2021); Goetzke et al. (2021)
PSMC3		NEUROSENSORY SYNDROME COMBINING DEAFNESS AND CATARACT	Kroll-Hermi et al. (2020)
PSMB1		MICROCEPHALY, INTELLECTUAL DISABILITY, DEVELOPMENTAL DELAY AND SHORT STATURE	Ansar et al. (2020)

The potential implication of the gene products in the regulation of innate and/or adaptive is indicated. When available, the OMIM (Online Mendelian Inheritance in Man^®) disorder number is also reported.