TABLE 5.

NDD-causing genes encoding components of the Umf1-conjugation pathway and associated syndromes.

Gene	OMIM	Syndrome	References	Described regulator of	References
UBA5	617132; 617133	DEVELOPMENTAL AND EPILEPTIC ENCEPHALOPATHY 44; SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 24	Duan et al. (2016); Muona et al. (2016)	NF-κB signaling	Li et al. (2017, 2019); Xi et al. (2013)
UFC1	618076	NEURODEVELOPMENTAL DISORDER WITH SPASTICITY AND POOR GROWTH	Nahorski et al. (2018)

The potential implication of the gene products in the regulation of innate and/or adaptive is indicated. When available, the OMIM (Online Mendelian Inheritance in Man^®) disorder number is also reported.