Figure 1:

genes associated with differentially methylated CpG sites. (A) Differentially methylated CpG sites between users and controls before abstinence. Gray circles are non-significant, light blue circles are nominally significant, and dark blue circles are Bonferroni significant (n = 163, P < 2.94 × 10⁻⁹). (B) Differentially methylated CpG sites between users and controls after abstinence. Gray circles are non-significant, pink circles are nominally significant, and red circles are Bonferroni significant (n = 127, P < 2.94 × 10⁻⁹)