Figure 2.
C. neoformans (Cn) Δsgl1 induces a pro-Inflammatory lung cytokine microenvironment in the host. CBA/J mice were intranasally infected with 5x105 CFU of either WT or Cn Δsgl1. Total lung tissue homogenates (n=3 mice/strain/timepoint) were analyzed using a Multiplex Elisa Array on days 2, 3, 4, 5, 6. and 14 post infection for various cytokines (A–E, J, K) and chemokines (F–I). Significance was determined by a two-way ANOVA using Šídák’s multiple comparisons test for P value adjustment. Graphed data represents the mean +/- SD, and significance is denoted as *P < 0.05; **P < 0.01; ***P < 0.005; ****P < 0.001.