Figure 4.

CD4⁺ T cells are necessary for clearance of C. neoforrnans (Cn) Δsgl1. CBA/J mice were depleted of adaptive lymphocytes [(A), B cells; (B), CD8⁺ T cells; (C), CD4⁺ T cells] and lung fungal burden analysis was determined for each condition. Significance was detemnined using a two-way ANOVA using Šídák’s multiple comparisons test for P value adjustment. All details of dosing frequency, antibody clone, or clodronate liposome configuration can be found in the material and methods section. Graphed data represents the mean+I-SD, and significance is denoted as ****P < 0.001.