Table 3.
Characteristics of LURIC study participants according to serum uromodulin (<146 or ≥146 ng/mL) and eGFR (<84 or ≥84 mL/min/1.73 m2) groups.
| Variable | Both high | Both low | eGFR low | sUmod low | Ppost-hoc | |||
|---|---|---|---|---|---|---|---|---|
| UHGH | ULGL | UHGL | ULGH | UHGH vs. UHGL | UHGH vs. ULGH | UHGL vs. ULGH | ||
| Age (years) | 57(9.76) | 68.2(8.69) | 67(8.03) | 58.7(10.3) | <0.001 | <0.001 | <0.001 | 0.003 |
| Male sex (%) | 74.6 | 65.8 | 57.7 | 80.4 | <0.001 | <0.001 | <0.001 | 0.009 |
| BMI (kg/m2) | 27(3.84) | 27.7(4.13) | 27.7(4.35) | 27.7(4.12) | <0.001 | 1 | 0.011 | 0.007 |
| LDL-C (mg/dl) | 119(34.8) | 113(34.3) | 117(34.7) | 116(32.4) | 0.001 | 0.88 | 0.691 | 0.221 |
| HDL-C (mg/dl) | 40(10.9) | 36.8(10.5) | 39.9(10.9) | 38.3(10.8) | <0.001 | 0.055 | 1 | 0.022 |
| TG (mg/dl) | 139(103–188) | 154(116–208) | 144(106–195) | 151(113–215) | <0.001 | 0.024 | 0.746 | <0.001 |
| systolic BP (mmHg) | 137(22.2) | 145(24.8) | 143(23.8) | 140(22.1) | <0.001 | 0.032 | <0.001 | 0.102 |
| diastolic BP (mmHg) | 81.1(11.1) | 80.6(11.7) | 81.5(11.8) | 81.1(10.8) | 0.482 | 0.948 | 0.935 | 1 |
| Magnesium (mmol/l) | 0.847(0.091) | 0.862(0.103) | 0.859(0.0945) | 0.834(0.0879) | <0.001 | <0.001 | 0.082 | 0.042 |
| Fasting glucose (mg/dl) | 99.7(92.1–110) | 105(95.2–126) | 102(93.8–117) | 104(94.7–122) | <0.001 | 0.272 | 0.002 | <0.001 |
| hsCRP (mg/l) | 2.28(1–6.33) | 5.25(2.12–10.7) | 3.03(1.45–8.3) | 3.06(1.22–7.69) | <0.001 | 0.619 | <0.001 | 0.006 |
| NT-proBNP (ng/ml) | 160(68–420) | 679(248–1,860) | 375(147–1,010) | 175(76–486) | <0.001 | <0.001 | <0.001 | 0.289 |
| Renin (pg/ml) | 17(9–34) | 23.5(12–59) | 18(9–41) | 18(10–35) | <0.001 | 0.931 | 0.227 | 0.61 |
| Angiotensin II (ng/L) | 20(12–35) | 20(13–34) | 20(13–35) | 19(12–34) | 0.152 | 0.813 | 0.45 | 0.965 |
| Noradrenalin (ng/l) | 276(199–380) | 339(232–500) | 334(233–477) | 281(199–394) | <0.001 | <0.001 | <0.001 | 0.999 |
| Albumin (g/dl) | 4.48(0.535) | 4.28(0.553) | 4.39(0.524) | 4.38(0.573) | <0.001 | 0.999 | 0.008 | 0.007 |
| GOT (U/l) | 11.8(7.49) | 11.7(7.4) | 12.5(9.94) | 11.7(6.77) | 0.251 | 0.276 | 0.338 | 0.988 |
| FV (U/dl) | 112(20.9) | 113(23) | 114(20.1) | 115(21.9) | 0.368 | 0.895 | 0.829 | 0.288 |
| Fatty liver index | 47.4(25.2–71.4) | 58(36.6–77.2) | 53.9(31.5–74.3) | 55.3(32.1–79.1) | <0.001 | 0.476 | 0.006 | <0.001 |
| eGFR (ml/min/1.73 m2) | 98.3(9.42) | 62(16.2) | 72(9.75) | 96.5(9.23) | <0.001 | <0.001 | <0.001 | 0.022 |
| Uromodulin (ng/ml) | 222(62.6) | 95.4(31.4) | 202(52.4) | 107(28.1) | <0.001 | <0.001 | <0.001 | <0.001 |
| CystatinC (mg/l) | 0.8(0.74–0.86) | 1.12(1–1.37) | 1.01(0.93–1.11) | 0.83(0.76–0.89) | <0.001 | <0.001 | <0.001 | 0.031 |
| Diabetes mellitus (%) | 28.1 | 51.9 | 41.1 | 39 | <0.001 | 0.475 | <0.001 | <0.001 |
| Coronary artery disease (%) | 71.7 | 83.6 | 76.1 | 80.2 | <0.001 | 0.097 | 0.097 | 0.001 |
| Heart failure (%) | 21.8 | 47.5 | 35.1 | 26.1 | <0.001 | 0.001 | <0.001 | 0.054 |
| Hypertension (%) | 62.4 | 81 | 77.8 | 70.3 | <0.001 | 0.005 | 0 | 0.003 |
| Smoking (active/ex/never, %) | 28.4/38.9/32.7 | 17.6/45.9/36.5 | 15.3/37.7/47 | 31.3/40.5/28.2 | <0.001 | <0.001 | <0.001 | 0.161 |
*P-value adjusted for multiple testing using the false-discovery-rate method; GOT, glutamate oxalacetate transaminase; FV, factor V; NT-proBNP, N-terminal pro brain natriuretic peptide; TG, triglycerides.