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. 2021 Sep 8;8:729030. doi: 10.3389/fmed.2021.729030

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Copyright © 2021 Sun, Xu, Tan, Xiang, Zhou, Dan, Guo, Tan and Deng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Orthogonal partial least squares discriminant analysis to identify optimal short-term prognostic parameters for hepatitis-B-related acute-on-chronic liver failure. OPLS-DA was conducted in the ACLF group (n = 108). Three dimensional scatter plot (A) distinguished non-survivors from survivors. Loading scatter plot (B) was used to compare the impact of each parameters on survival. Values in prediction were ranked in VIP plot (C). VIPpred > 1.0 was considered to have significant contributions to the outcome.