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. 2021 Sep 8;8:729030. doi: 10.3389/fmed.2021.729030

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Copyright © 2021 Sun, Xu, Tan, Xiang, Zhou, Dan, Guo, Tan and Deng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of sexual hormone levels. Comparison of sexual hormone levels were conducted in CHB cohort (n = 300) and HBV-ACLF group (n = 108). (A,B) Showed the baseline estradiol and testosterone levels in hepatitis B related acute-on-chronic liver failure (HBV-ACLF, n = 108) and non-ACLF group (n = 192). (C,D) Revealed the changes of estradiol and testosterone according to the number of organ failures. (E,F) Suggested that there was no significant difference of estradiol and testosterone levels among ACLF subtypes. (G) Showed the linear correlation between estradiol levels and traditional prognostic scores. (H) Showed the linear correlation between testosterone levels and traditional prognostic scores. *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001.