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. 2021 Sep 8;12:665160. doi: 10.3389/fimmu.2021.665160

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Copyright © 2021 Cao, Li, Baranova and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cross-trait meta-analysis of MDD and ADs. (A) Manhattan plot of meta-analysis of MDD with ADs. The x-axis is the chromosomal position of SNPs, and the y-axis is the significance of the SNPs (-log₁₀P). Protein-coding genes containing or adjacent to independent significant SNPs shared by two traits were annotated. PCDHA1_6: PCDHA1, PCDHA2, PCDHA3, PCDHA4, PCDHA5, and PCDHA6. (B) The 14q23 locus containing the ESR2 gene. Each SNP is colored based on the highest r² to one of the independent significant SNPs. (C) Enrichment of the 27 protein-coding genes in GWAS catalog gene sets.