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C57BL/6 male mice were treated as described in Figure 6. (A). Body weight of mice was monitored daily before treatment to evaluate the health status. *p < 0.05 (ANOVA, Dunnett test) vs vehicle-treated mice. (B) shows box plots of weight loss values at the time of killing(28 h and 5 days after infection) of vehicle- or roflumilast-treated mice. *p < 0.05 (Student’s t-test) vs vehicle-treated mice.
