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. 2021 Sep 8;11:733811. doi: 10.3389/fcimb.2021.733811

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Copyright © 2021 Smith, Price, Burrells, Faber, Hildersley, Chintoan-Uta, Chapuis, Stevens, Stevenson, Burgess, Innes, Nisbet and McNeilly

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A schematic of the development of ovine gastric and intestinal organoids for studying host-pathogen interactions. Stem cells isolated from sheep ileum crypts and abomasum gastric glands can be cultivated into tissue-specific organoids when grown in a three-dimensional culture system. Gastric and intestinal organoids can be co-cultured with pathogens to model host-parasite interactions in physiologically and biologically-relevant in vitro culture systems. Created with BioRender.com.