Table 1.

Folate-sensitive rare fragile sites known to be associated with CGG microsatellites.

Fragile site/disorder	Gene	References
FRA2A ID	AFF3	Metsu et al., 2014b
FRA7A autism spectrum disorder	ZNF713	Metsu et al., 2014a
FRA10A*	FRA10AC1	Sarafidou et al., 2004
FRA11A*	C11orf80	Debacker et al., 2007
FRA11B§	CBL2	Jones et al., 1994
FRA12A ID	DIP2B	Winnepenninckx et al., 2007
FRA16A*	XYLT1	Nancarrow et al., 1994
FRAXA ID/FMR1 disorders	FMR1	Verkerk et al., 1991
FRAXE ID	FMR2/AFF2	Knight et al., 1993
FRAXF*	FAM11A	Parrish et al., 1994; Shaw et al., 2002

^* not associated with disease.

^§ responsible for some cases of Jacobsen syndrome, a chromosome deletion syndrome.