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. 2021 Sep 8;12:732796. doi: 10.3389/fmicb.2021.732796

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Copyright © 2021 Pradhan, Margolin and Beuria.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Benzamide derivatives disrupt Z-rings by redistributing FtsZ to multiple cellular foci. Shown are micrographs of B. subtilis cells with fluorescently labeled Z-rings, grown with either no drug added or after 90 min incubation with compound 8, a benzodioxane-benzamide derivative (diagrammed below). Reproduced from Straniero et al. (2021), under Creative Commons License CC BY 4.0. The yellow arrow highlights a functional and morphologically normal Z-ring; the white arrow highlights disrupted FtsZ localization as multiple foci.