Table 4.

Subgroup analysis of pooled HR for melanoma patients with Ki-67 overexpression.

			Overall survival			Heterogeneity
Group factors	Subgroup	Studies	Pooled HR	P-value	95% CI	I2(%)	P	Effects model
All	All	7	2.92	0.000	[2.17-3.91]	27.30%	0.22	Fixed
region	Europe and America	6	2.72	0.000	[2.00-3.69]	9.80%	0.353	Fixed
	Asia	1	6.95	0.0004	[2.37-20.32]	NA	NA	NA
patients	>=100	3	2.759	0.000	[1.821-4.182]	40.10%	0.188	Fixed
	<100	4	3.084	0.000	[2.035-4.673]	37.20%	0.189	Fixed
median age	>=50	4	2.471	0.000	[1.727-3.535]	31.60%	0.223	Fixed
	<50	2	4.608	0.000	[2.525-8.409]	0.00%	0.366	Fixed
study type	prospective	2	1.982	0.001	[1.301-3.018]	0.00%	0.739	Fixed
	retrospective	5	4.219	0.000	[2.798-6.362]	0.00%	0.773	Fixed
ki-67%	>=25%	3	2.6	0.004	[1.361-4.969]	57.00%	0.1843	Random
	<25%	4	3.873	0.000	[2.483-6.042]	0.00%	0.843	Fixed
follow-up	>=48	2	4.413	0.000	[2.232-8.725]	0.00%	0.508	Fixed
	<48	4	2.408	0.000	[1.711-3.389]	0.00%	0.443	Fixed

NA, not available.