Table 4.
Other biological markers in patients with COVID-19 according to disease severity.
| Variable | Mild/moderate Median (IQR) N = 34 | Severe Median (IQR) N = 51 | Critical Median (IQR) N = 36 | P-value |
|---|---|---|---|---|
| Coagulation pathway factors (AU) | ||||
| Protein C | 593.84 (447.79-749.56) | 622.26 (518.46-762.62) | 458.50 (284.82-612.76) | 0.033 |
| Protein S | 492.35 (348.08-666.91) | 567.36 (440.58-693.27) | 436.56 (264.74-672.02) | 0.32 |
| Von Willebrand Factor | 331.93 (290.52-443.79) | 293.81 (211.85-388.86) | 456.50 (246.86-649.54) | 0.015 |
| Factor IX | 349.67 (234.93-515.41) | 433.18 (289.10-534.95) | 404.2 (262.50-502.60) | 0.56 |
| Hypoxia markers | ||||
| HIF-1a (pg/mL) | 1742.50 (401.06-4394.40) | 1022.00 (721.00-1862.00) | 922.00 (501.70-1432.30) | 0.50 |
| 8-hydroxy 2 deoxyguanosine (ng/mL) | 30.77 (23.27-37.42) | 42.55 (38.75-45.28) | 31.15 (22.74-45.30) | <0.001 |
| Muscle atrophy markers | ||||
| Atrogin-1 (ng/mL) | 51.38 (26.68-77.31) | 42.81 (27.29-56.28) | 70.16 (36.89-93.03) | 0.017 |
| Trim63 (pg/mL) | 103.6 (0.00-336.60) | 266.01 (99.48-602.71) | 918.60 (558.90-1096.80) | <0.001 |
| Neutrophil extracellular traps complexes (ODI) | ||||
| NETs (DNA-NE) | 0.83 (0.46-1.19) | 1.39 (0.89-1.73) | 1.11 (0.85-1.62) | <0.001 |